18. Genetic analysis of the ferrochelatase gene in eight Japanese patients from seven families with erythropoietic protoporphyria

投稿者: | 2020年1月17日
318件のコメント

18. Genetic analysis of the ferrochelatase gene in eight Japanese patients from seven families with erythropoietic protoporphyria Saruwatari H, Ueki Y, Yotsumoto S, Shimada T, Fukumaru S, Kanekura T, Kanzaki T.
The 32nd Annual Meeting of The Japanese Society for Investigative Dermatology（横浜市）
2007年4月

「18. Genetic analysis of the ferrochelatase gene in eight Japanese patients from seven families with erythropoietic protoporphyria」への318件のフィードバック

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    Understanding COSC Accreditation and Its Importance in Horology
    COSC Accreditation and its Stringent Criteria
    COSC, or the Controle Officiel Suisse des Chronometres, is the official Switzerland testing agency that certifies the precision and accuracy of wristwatches. COSC accreditation is a sign of excellent craftsmanship and trustworthiness in timekeeping. Not all watch brands pursue COSC certification, such as Hublot, which instead adheres to its own stringent standards with movements like the UNICO calibre, reaching comparable precision.

    The Science of Precision Chronometry
    The core system of a mechanical watch involves the mainspring, which delivers power as it loosens. This system, however, can be susceptible to environmental factors that may impact its precision. COSC-certified mechanisms undergo rigorous testing—over 15 days in various circumstances (5 positions, 3 temperatures)—to ensure their durability and dependability. The tests assess:

    Mean daily rate accuracy between -4 and +6 seconds.
    Mean variation, peak variation rates, and effects of thermal changes.
    Why COSC Certification Is Important
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    Presents exceptional dependability and accuracy.
    Provides guarantee of superiority across the entire design of the watch.
    Is likely to hold its worth more efficiently, making it a smart investment.
    Famous Chronometer Manufacturers
    Several famous manufacturers prioritize COSC certification for their watches, including Rolex, Omega, Breitling, and Longines, among others. Longines, for instance, provides collections like the Record and Soul, which highlight COSC-certified movements equipped with cutting-edge substances like silicon balance springs to boost durability and performance.

    Historical Context and the Evolution of Chronometers
    The notion of the chronometer dates back to the need for accurate timekeeping for navigation at sea, highlighted by John Harrison’s work in the 18th cent. Since the official establishment of Controle Officiel Suisse des Chronometres in 1973, the certification has become a benchmark for evaluating the precision of luxury timepieces, maintaining a legacy of superiority in watchmaking.

    Conclusion
    Owning a COSC-certified watch is more than an visual selection; it’s a commitment to quality and accuracy. For those appreciating precision above all, the COSC validation provides tranquility of mind, guaranteeing that each accredited timepiece will operate dependably under various circumstances. Whether for individual contentment or as an investment decision, COSC-accredited watches distinguish themselves in the world of horology, carrying on a legacy of meticulous timekeeping.

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